What Is 1-Bromo-3-methylbutane CAS 107-82-4 Used For in Pharmaceutical and Fragrance Synthesis?

Oct 19, 2026

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1-Bromo-3-methylbutane CAS 107-82-4, also called isoamyl bromide or isopentyl bromide, is a branched C5 primary alkyl bromide used as an alkylating agent for pharmaceuticals, dyes, fragrances, and agrochemical intermediates. Shanghai Arise New Material Co., Ltd. supplies 1-bromo-3-methylbutane as a colorless transparent liquid (C5H11Br, MW 151.04, typical purity ≥99%) for customers who need an isoamyl group rather than a straight pentyl chain.

 

1-Bromo-3-methylbutane CAS 107-82-4

 

In pharmaceutical and fine-chemical synthesis, 1-bromo-3-methylbutane installs a 3-methylbutyl (isoamyl) chain on nitrogen, oxygen, or carbon nucleophiles. That branched tail changes lipophilicity and odor compared with n-pentyl bromide. Process chemists should order CAS 107-82-4 so they do not receive 1-bromopentane or 2-bromo isomers that will fail a validated impurity method.

 

In fragrance and dye chemistry, the isoamyl fragment is familiar from banana- and fruit-type notes in related esters, but 1-bromo-3-methylbutane itself is a reactive alkylating agent, not a finished aroma chemical. It is used to build fragrance and dye intermediates. In agrochemical plants it can serve as a raw material toward pesticides, insecticides, and fungicides, again as an intermediate, not as a formulated crop-protection product.

 

Laboratory methods also list 1-bromo-3-methylbutane as an extraction solvent for polycyclic aromatic hydrocarbons in water (liquid-liquid microextraction with GC-MS), and in research routes such as 1-(3-methylbutyl)pyrrole synthesis. Bulk commercial demand is still driven by alkylation, not by analytical solvent use.

 

A practical specification includes EINECS 203-522-9, melting point about −112°C, boiling point 120–121°C, density about 1.261 g/mL, and assay ≥99%. Packing is commonly 1 L, 25 L, 200 L, or 1000 L IBC. Shelf life is typically 24 months in sealed storage.
 

Handling is not casual. 1-Bromo-3-methylbutane is a highly flammable liquid and vapor (flash point about 21°C, GHS Danger, Flammable Liquid Category 2). Store it tightly closed in a cool, dry, well-ventilated place, away from oxidizers, heat, sparks, and hot surfaces. Ground containers and control static. Vapor may irritate or burn skin and eyes and can cause dizziness in poorly ventilated rooms. Fire can release irritating bromine-containing gases. Keep the product locked, for trained staff only. Absorb spills with sand or diatomite; do not release to drains.

 

Shanghai Arise New Material Co., Ltd. offers samples, flexible MOQ, and customs documents (COA, MSDS, invoice, packing list). Courier or air is often 6–10 days; sea depends on destination.

 

If you need an isoamyl alkylating agent for pharmaceutical, fragrance, dye, or agrochemical intermediates, request 1-bromo-3-methylbutane CAS 107-82-4 from Arise New Material. Tell us the nucleophile class and water specification so the lot can be matched to your alkylation step.

 

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